Statistical challenges in the analysis of two-dimensional difference gel electrophoresis experiments

Fodor et al. present a study published in Bioinformatics on the statistical challenges in the analysis of two-dimensional difference gel electrophoresis experiments using the DeCyderTM software. A case study on the effect of smallpox vaccination is used to compare the results obtained from DeCyder to the results obtained by applying moderated t-tests adjusted for multiple comparisons to DeCyder output data that was additionally normalized.

Fodor IK, Nelson DO, Alegria-Hartman M, Robbins K, Langlois RG, Turteltaub KW, Corzett TH, McCutchen-Maloney SL. Statistical challenges in the analysis of two-dimensional difference gel electrophoresis experiments using DeCyderTM. Bioinformatics. 2005 Aug 9. [PubMed]